Structure and Reactivity of N-Heterocyclic Alkynyl Hypervalent Iodine Reagents

Structure and Reactivity of N-Heterocyclic Alkynyl Hypervalent Iodine Reagents
Ethynylbenziodoxol(on)e (EBX) cyclic hypervalent iodine reagents have grow to be in style reagents for the alkynylation of radicals and nucleophiles, however solely supply restricted potentialities for additional construction and reactivity fine-tuning. Herein, we report the synthesis of recent N -heterocyclic hypervalent iodine reagents with elevated structural flexibility based mostly on amide, amidine and sulfoximine scaffolds.
Strong state constructions of the reagents are reported and the evaluation of the I-C alkyne bond lengths allowed assessing the trans -effect of the completely different substituents. Molecular electrostatic potential (MEP) maps of the reagents, derived from DFT computations, revealed much less pronounced σ-hole areas for sulfonamide-based compounds.
Most reagents reacted nicely within the alkynylation of β-ketoesters. The alkynylation of thiols afforded extra variable yields, with compounds with a stronger σ-hole reacting higher. In metal-mediated transformations, the N -heterocyclic hypervalent iodine reagents gave inferior outcomes when in comparison with the O -based EBX reagents.

Bis(trifluoromethyl)amido Complexes of Copper and Silver: Steady and storable N(CF3)2 switch reagents

Fluorinated teams are important for drug design, agro-che-micals, and supplies science. The bis(trifluoro-methyl)–amino group is an instance for a steady group that has a excessive potential. Whereas the variety of molecules containing per-fluoro-alkyl, perfluoro-alkoxy, and different fluorinated teams is steadily growing, exampl-es with the N(CF3)2 group are uncommon.
One cause is that switch reagents are scarce and metal-based storable reagents are unknown. Right here, we current a set of CuI and AgI bis(trifluoromethyl)amido complexes stabilized by N- and P-donor ligands with un-pre-ce–dented stability. The complexes are steady solids that may even be manipulated in air for a short while. They’re bis(trifluoro-methyl)amination reagents as proven by nucleo-philic substitution and Sandmeyer reactions.
Along with a sequence of benzylbis(trifluoromethyl)amines, 2-bis(trifluoro-methyl)–amino acetate was obtained that upon hydrolysis offers the fluorinated amino acid N,N-bis(trifluoromethyl)glycine.

Diastereoselective Additions of Allylmagnesium Reagents to α-Substituted Ketones When Stereochemical Fashions Can not Be Used

The stereoselectivities of reactions of allylmagnesium reagents with chiral ketones can’t be simply defined by stereochemical fashions. Competitors experiments point out that the complexation step shouldn’t be reversible, so nucleophiles can’t entry the widest vary of doable encounter complexes and due to this fact can’t be analyzed simply utilizing obtainable fashions.
Structure and Reactivity of N-Heterocyclic Alkynyl Hypervalent Iodine Reagents
However, additions of allylmagnesium reagents to a ketone can nonetheless be stereoselective offered that the carbonyl group adopts a conformation that results in one face being fully blocked from the strategy of the allylmagnesium reagent.

Improvement of a triazinedione-based dehydrative condensing reagent containing 4-(dimethylamino)pyridine as an acyl switch catalyst

A brand new triazinedione-based reagent, (N,N’-dialkyl)triazinedione-4-(dimethylamino)pyridine (ATD-DMAP) was developed for the operationally easy dehydrative condensation of carboxylic acids. This reagent includes an ATD core and DMAP because the leaving group, which is liberated into the response system to speed up acyl switch reactions.
Upon including ATD-DMAP to a mix of carboxylic acids and alcohols within the presence of an amine base, the corresponding esters have been shaped quickly at room temperature. Furthermore, dehydrative condensation between carboxylic acids and amines utilizing ATD-DMAP proceeded in excessive yield.

N-Acyltriazinedione; a Novel Acylating Reagent Synthesized from a Triazinone-Kind Condensing Reagent

On this paper, we report the synthesis of N-acyltriazinedione through the sudden O-N acyl rearrangement of acyloxytriazinone and its utility as an acylating reagent. N-Acyltriazinedione might be remoted by silica gel column chromatography and reacts with amines within the absence of any base to provide the corresponding amides in good yields.

Tuning a pyrazoline-based fluorogenic reagent, 3-naphthyl-1-(4-trifluoromethyl)-5-(4-carboxy phenyl)-2-pyrazoline for delicate precolumn derivatization of aliphatic alcohols and hint evaluation by RP-HPLC with fluorescence detection

A brand new member of the pyrazoline household, 3-naphthyl-1-(4-trifluoromethyl)-5-(4-carboxy phenyl)-2-pyrazoline has been evaluated as a precolumn derivatization reagent for the evaluation of major alcohols utilizing HPLC. The simultaneous separation of eight alcohol derivatives (C1 -C8 ) inside 15 min was achieved on a reverse-phase C8 column with an isocratic elution mode.
The derivatives have been detected with fluorescence at an emission wavelength of 470 nm when excited at 360 nm. The identification of the corresponding derivatives was carried out by LC-MS/MS and all confirmed their attribute mum or dad peak in destructive ion mode. The proposed methodology was validated utilizing regular analytical instruments and was discovered to be glorious. As a preliminary utility, our methodology was used to find out ethanol focus in alcohol-containing sweets and cough syrup.

Comparative assessments of the biodistribution and toxicity of oxidized single-walled carbon nanotubes dispersed with two completely different reagents after intravenous injection

The current examine in contrast the consequences of two commonly-used dispersants, bovine serum albumin (BSA) and polyethylene glycol (PEG), on the biodistribution and toxicity of oxidized super-growth single-wall carbon nanotubes (oxSG) injected intravenously into mice over Three months. About 1-2% of the injected dose (ID) of oxSG dispersed in BSA (oxSG-BSA) was current within the lungs in any respect time factors.
Against this, about 15% of the ID of oxSG dispersed in PEG (oxSG-PEG) was current within the lungs at 1 day (D1), with accumulation lowering to about 5% of the ID at 90 days (D90). About 70-80% of the IDs of each oxSG-BSA and oxSG-PEG have been current within the liver at D1; by D90, about 15% of the IDs have been cleared slowly (oxSG-BSA) or quickly (oxSG-PEG). Within the spleen, about 7% of the IDs of each oxSG-BSA and oxSG-PEG have been current in any respect time factors.

Forget-Me-Notâ„¢ EvaGreen qPCR Master Mix (500 reactions)

31041-1 5x1mL
EUR 326.4
Description: Minimum order quantity: 1 unit of 5x1mL

Forget-Me-Notâ„¢ EvaGreen qPCR Master Mix (2000 reactions)

31041-20mL 2x10mL
EUR 592.8
Description: Minimum order quantity: 1 unit of 2x10mL

Forget-Me-Notâ„¢ EvaGreen qPCR Master Mix (100 reactions)

31041-T 1mL
EUR 136.8
Description: Minimum order quantity: 1 unit of 1mL

Fast Plus EvaGreen qPCR Master Mix with low Rox (500 rxn)

31014-1 5x1mL
EUR 524.4
Description: Minimum order quantity: 1 unit of 5x1mL

Fast Plus EvaGreen qPCR Master Mix with low Rox (5000 rxn)

31014-2 50x1mL
EUR 4291.2
Description: Minimum order quantity: 1 unit of 50x1mL

Fast Plus EvaGreen qPCR Master Mix with high Rox (500 rxn)

31015-1 5x1mL
EUR 524.4
Description: Minimum order quantity: 1 unit of 5x1mL

Fast Plus EvaGreen qPCR Master Mix with high Rox (5000 rxn)

31015-2 50x1mL
EUR 4291.2
Description: Minimum order quantity: 1 unit of 50x1mL

TaqProbe 2X qPCR MasterMix-No Dye

MasterMix-PS 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

KiloGreen 2X qPCR MasterMix-No Dye

MasterMix-KS 4 x 1.25 ml - 500 reactions (20 ul)
EUR 168

Fast Plus EvaGreen qPCR Master Mix with low Rox (100 rxn): (1mL)

31014-T 1mL
EUR 160.8
Description: Minimum order quantity: 1 unit of 1mL

BrightGreen 2X qPCR MasterMix-No Dye

MasterMix-S 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

BrightGreen 2X qPCR MasterMix-No Dye

MasterMix-S-XL 16 x 1.25 ml for 2000 reactions (20 ul)
EUR 451.2

Fast Plus EvaGreen qPCR Master Mix with High Rox (100 rxn): (1mL)

31015-T 1mL
EUR 160.8
Description: Minimum order quantity: 1 unit of 1mL

BrightGreen miRNA qPCR MasterMix-No Dye

MasterMix-mS 4 x 1.25 ml for 500 reactions
EUR 181.2

Forget-Me-Notâ„¢ EvaGreen qPCR Master Mix (Low ROX) (500 reactions)

9-31045
  • EUR 136.80
  • EUR 578.40
  • EUR 319.20
  • 1mL
  • 1X10mL
  • 5x1mL
Description: Minimum order quantity: 1 unit of 5x1mL

Fast EvaGreen Master Mix for qPCR, trial size (100 rxn)

31003-T 1ML
EUR 147.6
Description: Minimum order quantity: 1 unit of 1ML

Forget-Me-Notâ„¢ EvaGreen qPCR Master Mix with ROX (500 reactions)

31042-1 5x1mL
EUR 326.4
Description: Minimum order quantity: 1 unit of 5x1mL

Forget-Me-Notâ„¢ EvaGreen qPCR Master Mix with ROX (200 reactions)

31042-20mL 2x10mL
EUR 592.8
Description: Minimum order quantity: 1 unit of 2x10mL

Forget-Me-Notâ„¢ EvaGreen qPCR Master Mix with ROX (100 reactions)

31042-T 1mL
EUR 136.8
Description: Minimum order quantity: 1 unit of 1mL

Forget-Me-Notâ„¢ EvaGreen qPCR Master Mix (High ROX) (500 reactions)

9-31046
  • EUR 136.80
  • EUR 578.40
  • EUR 319.20
  • 1mL
  • 1X10mL
  • 5x1mL
Description: Minimum order quantity: 1 unit of 5x1mL

Fast Plus EvaGreen Master Mix for qPCR with Rox (200 rxn)

31014 2x1mL
EUR 273.6
Description: Minimum order quantity: 1 unit of 2x1mL

BrightGreen Express 2X qPCR MasterMix-No Dye

MasterMix-ES 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

qPCR Master Mix E1 (SafeLine: EvaGreen, dUTP), packed in 1,25 ml vials

S150 100 rcs (2,5 ml)
EUR 165.6

qPCR Master Mix E1 (SafeLine: EvaGreen, dUTP), packed in 1,25 ml vials

S150L 500 rcs (12,5 ml)
EUR 627.6

Fast Plus EvaGreen Master Mix for qPCR with High Rox (200 rxn)

31015 2x1mL
EUR 273.6
Description: Minimum order quantity: 1 unit of 2x1mL

qPCR Master Mix E5 (EvaGreen, dUTP, 100 nM LOW ROX), packed in 1,25 ml vials

S175 100 rcs (2,5 ml)
EUR 165.6

qPCR Master Mix E5 (EvaGreen, dUTP, 100 nM LOW ROX), packed in 1,25 ml vials

S175L 500 rcs (12,5 ml)
EUR 627.6

qPCR Master Mix E2 (SafeLine: EvaGreen, dUTP, UNG), packed in 1,25 ml vials

S160 100 rcs (2,5 ml)
EUR 190.8

qPCR Master Mix E2 (SafeLine: EvaGreen, dUTP, UNG), packed in 1,25 ml vials

S160L 500 rcs (12,5 ml)
EUR 734.4

qPCR Master Mix E6 (EvaGreen, dUTP, UNG, 100 nM LOW ROX), packed in 1,25 ml vials

S185 100 rcs (2,5 ml)
EUR 190.8

qPCR Master Mix E6 (EvaGreen, dUTP, UNG, 100 nM LOW ROX), packed in 1,25 ml vials

S185L 500 rcs (12,5 ml)
EUR 734.4

Green-2-Go qPCR Mastermix-no Dye (500X20ul Rxn)

QPCR006-NODYE 4X1.25ml
EUR 326.22

qPCR Master Mix E3 (SafeLine: EvaGreen, dUTP, 500 nM ROX), packed in 1,25 ml vials

S170 100 rcs (2,5 ml)
EUR 165.6

qPCR Master Mix E3 (SafeLine: EvaGreen, dUTP, 500 nM ROX), packed in 1,25 ml vials

S170L 500 rcs (12,5 ml)
EUR 627.6

qPCR Master Mix E4 (SafeLine: EvaGreen, dUTP, UNG, 500 nM ROX), packed in 1,25 ml vials

S180 100 rcs (2,5 ml)
EUR 190.8

qPCR Master Mix E4 (SafeLine: EvaGreen, dUTP, UNG, 500 nM ROX), packed in 1,25 ml vials

S180L 500 rcs (12,5 ml)
EUR 734.4

HotTaq EvaGreen qPCR Mix (no ROX)

BT11102 250rxn
EUR 147.6
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

Green-2-Go TaqProbe qPCR Mastermix-no Dye (500X20ul Rxn)

QPCR005-NODYE 4X1.25ml
EUR 303.25

TaqProbe 5X qPCR MasterMix-ROX

MasterMix-5P 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 255.6

BrightGreen 5X qPCR MasterMix-ROX

MasterMix-5R 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 255.6

TaqProbe 5X qPCR MasterMix-iCycler

MasterMix-5PC 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 255.6

TaqProbe 5X qPCR MasterMix-Multiplex

MasterMix-5PM 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 255.6

BrightGreen 5X qPCR MasterMix-iCycler

MasterMix-5C 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 255.6

TaqProbe 5X qPCR MasterMix-Low ROX

MasterMix-5PL 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 255.6

BrightGreen 5X qPCR MasterMix-Low ROX

MasterMix-5L 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 255.6

HotTaq EvaGreen qPCR Mix (ROX)

BT11101 250rxn
EUR 147.6
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

QPCR Kit QPCR Mastermix DNA

MOL6354 EACH
EUR 278.4

HotTaq EvaGreen qPCR Mix (Capillary)

BT11103 250rxn
EUR 147.6
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq EvaGreen qPCR Universal Mix

BT11104 250rxn
EUR 165.6
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

BlasTaq 2X qPCR MasterMix

E36G891 500 rxn (4 x 1.25 ml)
EUR 171.43

BlasTaq 2X qPCR MasterMix

E36G893 5,000 rxn (50.0 ml)
EUR 1128.57

BlasTaq Probe 2X qPCR MasterMix

E36G890 4 x 1.25 ml
EUR 171.43

TaqProbe 2X qPCR MasterMix-ROX

MasterMix-P 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

KiloGreen 2X qPCR MasterMix-ROX

MasterMix-KR 4 x 1.25 ml - 500 reactions (20 ul)
EUR 168

BrightGreen 2X qPCR MasterMix-ROX

MasterMix-R 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

BrightGreen 2X qPCR MasterMix-ROX

MasterMix-R-XL 16 x 1.25 ml for 2000 reactions (20 ul)
EUR 451.2

Bio-Star Mastermix with SYBR (2X) no dye

Y210 100 rcs (2,5 ml)
EUR 106.8

TaqProbe 2X qPCR MasterMix-iCycler

MasterMix-PC 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

KiloGreen 2X qPCR MasterMix-iCycler

MasterMix-KC 4 x 1.25 ml - 500 reactions (20 ul)
EUR 168

BrightGreen miRNA qPCR MasterMix-ROX

MasterMix-mR 4 x 1.25 ml for 500 reactions
EUR 181.2

TaqProbe 2X qPCR MasterMix-Multiplex

MasterMix-PM 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

BrightGreen 2X qPCR MasterMix-iCycler

MasterMix-iC 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

BrightGreen 2X qPCR MasterMix-iCycler

MasterMix-iC-XL 16 x 1.25 ml for 2000 reactions (20 ul)
EUR 451.2

TaqProbe 2X qPCR MasterMix-Low ROX

MasterMix-PL 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

Green-2-Go qPCR Mastermix (500X20ul Rxn)

QPCR004-S 4X1.25ml
EUR 303.25

KiloGreen 2X qPCR MasterMix-Low ROX

MasterMix-KL 4 x 1.25 ml - 500 reactions (20 ul)
EUR 168

BrightGreen miRNA qPCR MasterMix-iCycler

MasterMix-mC 4 x 1.25 ml for 500 reactions
EUR 181.2

BrightGreen 2X qPCR MasterMix-Low ROX

MasterMix-LR 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

BrightGreen 2X qPCR MasterMix-Low ROX

MasterMix-LR-XL 16 x 1.25 ml for 2000 reactions (20 ul)
EUR 451.2

QPCR Kit QRT-PCR Mastermix RNA

MOL6356 EACH
EUR 307.2

BrightGreen miRNA qPCR MasterMix-Low ROX

MasterMix-mL 4 x 1.25 ml for 500 reactions
EUR 181.2

BrightGreen Express 2X qPCR MasterMix-ROX

MasterMix-ER 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

BrightGreen Express 2X qPCR MasterMix-iCycler

MasterMix-EC 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

BrightGreen Express 2X qPCR MasterMix-Low ROX

MasterMix-EL 4 x 1.25 ml for 500 reactions (20 ul)
EUR 168

Real Time PCR mastermix 2x, (No ROX), 100RXNs, optimized ready-to-use mastermix containing unique reaction buffer, dNTP, Hot-Start Taq DNA polymerase, and QPCR dye

ACT-RT400RF each
EUR 261.6

Hotstart PCR MasterMix (Dye), 2× Flash

W3007-1 1 ml
EUR 49

Hotstart PCR MasterMix (Dye), 2× Flash

W3007-10 10 ml
EUR 169

2X PCR Taq MasterMix with dye

G013-dye 5.0 ml (200 Rxns)
EUR 104.4

2X PCR Taq MasterMix with dye

G900-dye 25.0 ml (1000 Rxns)
EUR 246

Green-2-Go qPCR Mastermix-ROX (500X20ul Rxn)

QPCR001-R 4X1.25ml
EUR 303.25

Kodaq 2X PCR MasterMix with dye

G497-dye 5.0 ml (200 Rxns)
EUR 189.6

2X PCR TaqFast MasterMix with dye

G280-dye 5.0 ml (200 Rxns)
EUR 160.8

Green-2-Go qPCR Mastermix-iCycler (500X20ul Rxn)

QPCR003-iC 4X1.25ml
EUR 303.25

2X PCR HotStart MasterMix with dye

G906-dye 5.0 ml (200 Rxns)
EUR 189.6

Green-2-Go qPCR Mastermix-Low ROX (500X20ul Rxn)

QPCR002-L 4X1.25ml
EUR 303.25

2X PCR Taq Plus MasterMix with dye

G014-dye 5.0 ml (200 Rxns)
EUR 127.2

2X PCR Taq Plus MasterMix with dye

G901-dye 25.0 ml (1000 Rxns)
EUR 358.8

HotTaq EvaGreen HRM Mix (no ROX)

BT11202 250rxn
EUR 147.6
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

Green-2-Go 1-Step qRT-PCR Mastermix-No Dye (100X20ul Rxn)

QPCR007-NODYE 100Rxn
EUR 287.08

2X PCR Bestaq™ MasterMix with dye

G464-dye 5.0 ml (200 Rxns)
EUR 189.6

2X PCR Precision™ MasterMix with dye

G124-dye 5.0 ml (200 Rxns)
EUR 195.6

2X PCR SensTaq HotStart MasterMix with Dye

G939-Dye 5.0 ml (200 Rxns)
EUR 189.6

Green-2-Go 1-Step TaqProbe qRT-PCR Mastermix-no Dye (100X20ul Rxn)

QPCR008-NODYE 100Rxn
EUR 341.88

5X All-In-One RT MasterMix

G485 25 x 10 ul reactions
EUR 79.2

5X All-In-One RT MasterMix

G486 100 x 10 ul reactions
EUR 126

5X All-In-One RT MasterMix

G490 200 x 10 ul reactions
EUR 169.2

5X All-In-One RT MasterMix

G590 1000 x 10 ul reactions
EUR 548.4

All-In-One 5X RT MasterMix

E36G592 100 rxn
EUR 242.86

Real-Time PCR Mastermix 2x, Regular Level of Rox, 100RXNs, optimized ready-to-use mastermix containing unique reaction buffer, dNTP, Hot-Start Taq DNA polymerase, and QPCR dye

ACT-RT400 each
EUR 261.6

Real-Time PCR Mastermix 2x, Low Level of Rox , 100RXNs, optimized ready-to-use mastermix containing unique reaction buffer, dNTP, Hot-Start Taq DNA polymerase, and QPCR dye

ACT-RT400LR each
EUR 261.6

EvaGreen, 2000X in DMSO

31019 50uL
EUR 294
Description: Minimum order quantity: 1 unit of 50uL

One.Step RT-qPCR Kit with EvaGreen (2X concentrated)

105-520 2 x 1,25 ml
EUR 549.6

One.Step RT-qPCR Kit with EvaGreen (2X concentrated)

105-522 10 x 1,25 ml
EUR 2062.8

5X All-In-One RT MasterMix (100x10ul Rxns)

HRT100-10 100x10ulRxns
EUR 207.9

5X All-In-One RT MasterMix (200x10ul Rxns)

HRT200-10 200x10ulRxns
EUR 303.6

One.Step RT-qPCR with EvaGreen / HighROX (2X concentrated)

105-530 2 x 1,25 ml
EUR 512.4

One.Step RT-qPCR with EvaGreen / HighROX (2X concentrated)

105-532 10 x 1,25 ml
EUR 1982.4

5X All-In-One RT MasterMix (25x10ul Rxns)

HRT025-10 25x10ulRxns
EUR 103.5

EvaGreen, 20X in water: (5x1mL)

31000 5x1ML
EUR 312
Description: Minimum order quantity: 1 unit of 5x1ML

HotTaq EvaGreen HRM Mix (ROX)

BT11201 250rxn
EUR 147.6
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

5X All-In-One RT MasterMix (with Cell Lysis Kit)

HRT100-20L 100x20ulRxns, 100prep
EUR 355.8

Evo? RT Mastermix

M1170-100 each
EUR 424.8

Evo? RT Mastermix

M1170-200 each
EUR 529.2

Evo? RT Mastermix

M1170-25 each
EUR 320.4

5X All-In-One RT MasterMix (with ExCellenCT Lysis Kit)

G916 25 Preps 100 x 20 ul reactions
EUR 222

EvaGreen® Plus, 20X in Water, 1 mL

31077-T 1ML
EUR 107
Description: N/A
The toxicities of oxSG-BSA and oxSG-PEG have been comparable: no apparent indicators of irritation have been noticed on histological assessments of the lungs, liver, and spleen and on measurements of cytokine exercise in blood plasma and tissue lysates. Concentrations of aspartate transaminase barely elevated at a while factors in blood plasma, suggesting that oxSG-BSA and oxSG-PEG have been barely hepatoxic. Taken collectively, these outcomes indicated that the dispersants had restricted impact on the biodistribution and toxicity of oxSGs.

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